"Native Science" is a historic and simultaneously contemporary body of understandings and practices focused on perpetuating a dynamic yet sustainable relationship with the natural world. It is this understanding of "relationships" that synergistically bind natural forces, human community and other forms of life that has formed the historic foundation for Indigenous people's ability to survive and even thrive in almost every habitat on Earth. An open exploration of the cultural history of "Indigenous Science" offers perspectives and insights that can help us collectively work toward solutions at this time of global environmental crisis.